Gene information
Official symbol LGALS3
Official full name galectin 3
Gene type protein-coding gene
Chromosome14q22.3
Alias symbolMAC-2; GALIG
Previous symbolLGALS2
Gene familyReceptor ligands; Galectins
Resources
Entrez Gene 3958
HGNC HGNC:6563
Ensembl ENSG00000131981
Vega OTTHUMG00000171030
UCSC uc001xbr.4
GO terms: 107 records
GO Description Category LogP Number of genes Detail
GO:0001772 immunological synapse GO Cellular Components -2.58671999 4 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002698 negative regulation of immune effector process GO Biological Processes -11.7829906 16 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010921 regulation of phosphatase activity GO Biological Processes -3.30329288 6 More
GO:0010923 negative regulation of phosphatase activity GO Biological Processes -2.02099167 3 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0019865 immunoglobulin binding GO Molecular Functions -2.55598907 3 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0019903 protein phosphatase binding GO Molecular Functions -3.28869574 16 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030246 carbohydrate binding GO Molecular Functions -4.83003123 14 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031334 positive regulation of protein-containing complex assembly GO Biological Processes -8.84926570 16 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032515 negative regulation of phosphoprotein phosphatase activity GO Biological Processes -2.45482288 3 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0035303 regulation of dephosphorylation GO Biological Processes -3.02544423 7 More
GO:0035304 regulation of protein dephosphorylation GO Biological Processes -2.33647794 5 More
GO:0035308 negative regulation of protein dephosphorylation GO Biological Processes -2.12309907 3 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043236 laminin binding GO Molecular Functions -4.54309219 5 More
GO:0043254 regulation of protein-containing complex assembly GO Biological Processes -7.63830100 21 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043666 regulation of phosphoprotein phosphatase activity GO Biological Processes -2.27622518 4 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045806 negative regulation of endocytosis GO Biological Processes -6.50553130 8 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048246 macrophage chemotaxis GO Biological Processes -8.11586193 6 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050840 extracellular matrix binding GO Molecular Functions -6.18341292 8 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050868 negative regulation of T cell activation GO Biological Processes -5.59075646 10 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070228 regulation of lymphocyte apoptotic process GO Biological Processes -9.74543052 11 More
GO:0070232 regulation of T cell apoptotic process GO Biological Processes -7.96781477 8 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0090279 regulation of calcium ion import GO Biological Processes -9.31154255 13 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:0101003 ficolin-1-rich granule membrane GO Cellular Components -1.86130079 7 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903076 regulation of protein localization to plasma membrane GO Biological Processes -2.83846671 6 More
GO:1903078 positive regulation of protein localization to plasma membrane GO Biological Processes -2.45650021 8 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904375 regulation of protein localization to cell periphery GO Biological Processes -3.14645923 7 More
GO:1904377 positive regulation of protein localization to cell periphery GO Biological Processes -2.16161219 8 More
GO:1905475 regulation of protein localization to membrane GO Biological Processes -3.01117711 17 More
GO:1905477 positive regulation of protein localization to membrane GO Biological Processes -1.94173448 10 More
GO:1905517 macrophage migration GO Biological Processes -7.27705643 6 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
belapectin TTD view
lactose, anhydrous DTC 1738586221524586 view
Related studies: 38 records
Molecular factor Omics type Application Objective MI type Reference
LGALS3 transcriptomics atrial fibrillation[prognosis (bad)] acute myocardial infarction Szadkowska I et al. Cardiol J. 2013
LGALS3 transcriptomics diuretics treatment[prognosis (bad)] acute myocardial infarction Szadkowska I et al. Cardiol J. 2013
galectin-3 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tsai TH et al. J Atheroscler Thromb. 2012
galectin-3 proteomics medium predictor reduced left ventricular ejection fraction[prognosis (bad)] acute ST elevation myocardial infarction Tsai TH et al. J Atheroscler Thromb. 2012
galectin-3 proteomics medium predictor major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Tsai TH et al. J Atheroscler Thromb. 2012
galectin-3 proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Weir RA et al. Circ Heart Fail. 2013
galectin-3 proteomics good predictor recurrent myocardial infarction[prognosis (bad)] acute myocardial infarction Szadkowska I et al. Biomarkers. 2013
galectin-3 proteomics inflammation[prognosis (bad)] acute myocardial infarction Alturfan AA et al. Lab Med. 2014
galectin-3 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Milner TD et al. Acta Cardiol. 2014
galectin-3 proteomics myocardial reperfusion[prognosis (good)] acute ST elevation myocardial infarction Milner TD et al. Acta Cardiol. 2014
galectin-3 proteomics infarct size[other] acute myocardial infarction van der Velde AR et al. Clin Chim Acta. 2016
galectin-3 proteomics left ventricular ejection fraction[other] acute myocardial infarction van der Velde AR et al. Clin Chim Acta. 2016
galectin-3 proteomics poor predictor death[prognosis (bad)] acute myocardial infarction Lisowska A et al. Atherosclerosis. 2016
galectin-3 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Winter MP et al. Eur J Clin Invest. 2016
galectin-3 proteomics old myocardial infarction[diagnosis] old myocardial infarction Winter MP et al. Eur J Clin Invest. 2016
galectin-3 proteomics good predictor left ventricular remodeling[prognosis (bad)] acute anterior ST elevation myocardial infarction Di Tano G et al. Heart. 2017
galectin-3 proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Bivona G et al. Arch Med Res. 2016
galectin-3 proteomics troponin I, cardiac muscle[other] acute ST elevation myocardial infarction Bivona G et al. Arch Med Res. 2016
galectin-3 proteomics estimated glomerular filtration rate[other] acute ST elevation myocardial infarction Bivona G et al. Arch Med Res. 2016
galectin-3 proteomics diabetes mellitus[prognosis (bad)] acute myocardial infarction Laake K et al. JRSM Cardiovasc Dis. 2017
galectin-3 proteomics dyspnoea[other] acute myocardial infarction Laake K et al. JRSM Cardiovasc Dis. 2017
galectin-3 proteomics omega-3 fatty acid[other] acute myocardial infarction Laake K et al. JRSM Cardiovasc Dis. 2017
galectin-3 proteomics poor predictor atrial fibrillation[prognosis (bad)] acute non-ST elevation myocardial infarction Pavlovic M et al. Sci Rep. 2017
galectin-3 proteomics good predictor adverse events[prognosis (bad)] acute anterior ST elevation myocardial infarction Di Tano G et al. Biomark Med. 2018
galectin-3 proteomics adverse events[prognosis (bad)] acute myocardial infarction Gagno G et al. J Clin Med. 2019
galectin-3 proteomics heart failure[prognosis (bad)] myocardial infarction Asleh R et al. J Am Coll Cardiol. 2019
galectin-3 proteomics death[prognosis (bad)] myocardial infarction Asleh R et al. J Am Coll Cardiol. 2019
galectin-3 proteomics medium predictor left ventricular remodeling[prognosis (bad)] acute myocardial infarction Andrejic OM et al. Sci Rep. 2019
galectin-3 proteomics good predictor cardiovascular death;heart failure hospitalization[prognosis (bad)] acute ST elevation myocardial infarction Tyminska A1 et al. Pol Arch Intern Med. 2019
galectin-3 proteomics heart failure[prognosis (bad)] acute ST elevation myocardial infarction Tyminska A et al. Dis Markers. 2019
galectin-3 proteomics incomplete ST resolution[prognosis (bad)] acute ST elevation myocardial infarction Turan Y et al. Adv Clin Exp Med. 2020
galectin-3 proteomics systemic vascular resistance[other] acute myocardial infarction Huttin O et al. PLoS One. 2020
galectin-3 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Pecherina T et al. Diagnostics (Basel). 2020
galectin-3 proteomics adverse events[prognosis (bad)] acute myocardial infarction Swiecki P et al. J Clin Med. 2020
galectin-3 proteomics medium predictor SYNTAX score[other] acute non-ST elevation myocardial infarction Quisi A et al. Turk Kardiyol Dern Ars. 2020
galectin-3 proteomics coronary vessel lesion[other] acute ST elevation myocardial infarction Ben Ahmed H et al. Tunis Med. 2020
NC_000014.9:g.55112795A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Djordjevic A et al. Mol Biol Rep. 2018
NC_000014.9:g.55147918C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Djordjevic A et al. Mol Biol Rep. 2018
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